细胞膜力学和机械感觉传导。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2020-01-01 DOI:10.1016/bs.ctm.2020.08.002
Boris Martinac, Yury A Nikolaev, Giulia Silvani, Navid Bavi, Valentin Romanov, Yoshitaka Nakayama, Adam D Martinac, Paul Rohde, Omid Bavi, Charles D Cox
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引用次数: 24

摘要

机械生物学的快速发展汇集了许多科学和工程学科,以更好地理解机械力在不同形式的生命的功能和进化中所起的作用。工程师设计的新工具有助于开发新的方法和技术来研究生物细胞和组织的机械特性。这种多学科的方法清楚地表明,细胞力学与细胞内信号通路密切相关,细胞内信号通路直接调节基因表达,以响应来自细胞内外的机械刺激。机械刺激作用于机械感受器,机械感受器将这些刺激转化为细胞内信号。在本章中,我们回顾了当前关于细胞力学的知识,以及细胞力学在机械敏感离子通道的功能中所起的作用,细胞力学是一类特殊的机械受体,在毫秒时间尺度上作为机械刺激的分子传感器。
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Cell membrane mechanics and mechanosensory transduction.

The rapid progress in mechanobiology has brought together many scientific and engineering disciplines to work hand in hand toward better understanding of the role that mechanical force plays in functioning and evolution of different forms of life. New tools designed by engineers helped to develop new methods and techniques for investigation of mechanical properties of biological cells and tissues. This multidisciplinary approach made it clear that cell mechanics is tightly linked to intracellular signaling pathways, which directly regulate gene expression in response to mechanical stimuli originating outside or inside the cells. Mechanical stimuli act on mechanoreceptors which convert these stimuli into intracellular signals. In this chapter, we review the current knowledge about cell mechanics and the role cell mechanics plays for the function of mechanosensitive ion channels as a special class of mechanoreceptors functioning as molecular transducers of mechanical stimuli on a millisecond timescale.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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