g蛋白偶联受体命中发现的化学基因组学策略。

Ernst Schering Research Foundation workshop Pub Date : 2006-01-01 DOI:10.1007/978-3-540-37635-4_2

W Guba

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引用次数: 3

摘要

通过化学基因组学靶向蛋白质超家族是基于基因序列和配体分子结构的相似性聚类。靶标和配体簇都是通过生成化学型与靶面板的结合亲和谱来连接的。这种多维相似性范式的应用将在Lead Generation的背景下描述，以确定g蛋白偶联受体的新化学打击类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chemogenomics strategies for G-protein coupled receptor hit finding.

Targeting protein superfamilies via chemogenomics is based on a similarity clustering of gene sequences and molecular structures of ligands. Both target and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.

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Ernst Schering Research Foundation workshop

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