日益冲突:在骨科创伤协会年会上报告的利益冲突分析。

Erik N Kubiak, Samuel S Park, Kenneth Egol, Joseph D Zuckerman, Kenneth J Koval
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摘要

目的:确定自1993年利益冲突(COI)报告政策建立以来,骨科创伤协会年会上提出的骨科创伤研究的行业赞助趋势。背景:工业界在骨科基础科学和临床研究的资助方面发挥着重要作用。本研究的目的是分析骨科创伤协会(OTA)年会最终议程中记录的产业支持在骨科研究中的作用,确定OTA所接受的论文和海报中COI的发生率和性质,并报告自1993年披露政策颁布以来报告频率的变化。方法:本文分析了自1993-2002年采用报告政策以来所有年份的COI。从1993年到1998年,在骨科创伤协会年会上发表的海报和论文的作者被要求披露超过500美元的COI,没有记录货币分配的类型。从1999年到2002年,海报和论文的作者必须承认COI的类型:1。研究经费,2。2 .杂项非收入支助;版税,4。股票,和5。顾问费用。每年记录所有COI类别,使用线性回归来确定汇总数据中趋势的显著性。结果:1993年至2002年间,具有COI的论文在OTA上被接受和发表的比例有所增加。报告COI的论文数量从1993年的7.6%上升到2002年的12.6% (p = 0.0129)。在同一时期,患有COI的海报数量没有显著增加。自一九九九年修订报告制度以来,劳工参与的性质并无改变。1993年至2002年间,没有观察到NIH或OTA拨款分配的趋势。讨论与结论:产业界在骨科研究的资助中扮演着越来越重要的角色。大多数工业支持是以研究补助金的形式提供的。公共部门对科学研究越来越多的工业支持是值得赞扬的,只要它不导致可能对工业赞助者不利的信息的隔离和压制。
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Increasingly conflicted: an analysis of conflicts of interest reported at the annual meetings of the Orthopaedic Trauma Association.

Purpose: To identify trends in industry sponsorship of orthopaedic trauma research presented at the annual meetings of the Orthopaedic Trauma Association since the establishment of conflict of interest (COI) reporting policies in 1993.

Background: Industry plays a large role in funding orthopaedic basic science and clinical research. The purpose of this study was to analyze the role of industrial support in orthopaedic research as documented in the final programs of the annual meetings of the Orthopaedic Trauma Association (OTA), determine the incidence and nature of COI in the papers and posters accepted for OTA presentation, and report any changes in the frequency of reporting since disclosure policies were enacted in 1993.

Methods: This paper analyzes COI for all years since the adoption of the reporting policies 1993-2002. From 1993-1998, presenters of posters and papers presented at the Orthopaedic Trauma Association annual meetings were required to disclose COI greater than dollar 500, the type of monetary distribution was not recorded. From 1999-2002, presenters of posters and papers were required to acknowledge the type of COI: 1. research grant, 2. miscellaneous non-income support, 3. royalties, 4. stock, and 5. consultant fees. All COI categories were recorded for each year Linear regression was used to determine significance of trends in the pooled data.

Results: There was an increase in the percentage of papers accepted and presented at the OTA between 1993 and 2002 with COI. The number of papers reporting COI rose from 7.6% in 1993 to 12.6% in 2002 (p = 0.0129). There was no significant increase in posters with COI over that same time period. No changes were observed in the nature of industrial involvement since the change in reporting enacted in 1999. There were no observed trends in NIH or OTA grant distribution between 1993 and 2002.

Discussion and conclusion: Industry is playing an increasing role in the funding oforthopaedic research. The majority of industrial support is in the form of research grants. The increasing industrial support of scientific research in the public sector is to be applauded as long as it does not lead to the sequestering and suppression of information that may be disadvantageous to the industrial sponsor.

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