{"title":"将临床前数据外推到临床现实转化科学。","authors":"T Singer","doi":"10.1007/978-3-540-49529-1_1","DOIUrl":null,"url":null,"abstract":"<p><p>Human and animal in vitro models are potentially powerful preclinical tools: prediction of pharmacological behaviour of drugs; selection of animal species most closely related to humans based on metabolic patterns; prediction of drug interactions and explanation of metabolic origins of interindividual variabilities in pharmacological activity. Extrapolation of preclinical data into clinical reality is a translational science and remains an ultimate challenge in drug development.</p>","PeriodicalId":80277,"journal":{"name":"Ernst Schering Research Foundation workshop","volume":" 59","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-540-49529-1_1","citationCount":"3","resultStr":"{\"title\":\"Extrapolation of preclinical data into clinical reality translational science.\",\"authors\":\"T Singer\",\"doi\":\"10.1007/978-3-540-49529-1_1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human and animal in vitro models are potentially powerful preclinical tools: prediction of pharmacological behaviour of drugs; selection of animal species most closely related to humans based on metabolic patterns; prediction of drug interactions and explanation of metabolic origins of interindividual variabilities in pharmacological activity. Extrapolation of preclinical data into clinical reality is a translational science and remains an ultimate challenge in drug development.</p>\",\"PeriodicalId\":80277,\"journal\":{\"name\":\"Ernst Schering Research Foundation workshop\",\"volume\":\" 59\",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/978-3-540-49529-1_1\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ernst Schering Research Foundation workshop\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-540-49529-1_1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ernst Schering Research Foundation workshop","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-540-49529-1_1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Extrapolation of preclinical data into clinical reality translational science.
Human and animal in vitro models are potentially powerful preclinical tools: prediction of pharmacological behaviour of drugs; selection of animal species most closely related to humans based on metabolic patterns; prediction of drug interactions and explanation of metabolic origins of interindividual variabilities in pharmacological activity. Extrapolation of preclinical data into clinical reality is a translational science and remains an ultimate challenge in drug development.
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