对呼吸兴奋剂多巴胺的新认识

C. Spencer Yost
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引用次数: 107

摘要

一些危及生命的临床疾病可能可以用一种可以刺激呼吸驱动的药物来治疗。这些包括继发于慢性阻塞性肺疾病的急性呼吸衰竭、麻醉后呼吸抑制和早产儿呼吸暂停。Doxapram用于治疗这些疾病已有40多年的历史,与其他可用的药物相比,它的副作用很小。一般来说,doxapram的使用仅限于重症监护、麻醉后护理和新生儿重症监护病房的患者。近年来的基础科学研究在了解多巴胺促呼吸作用的分子机制方面取得了长足的进展。尽管基于这种新的认识,doxapram不太可能经历临床复兴,但它代表了我们对呼吸控制知识的重大进步。
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A New Look at the Respiratory Stimulant Doxapram

A number of life-threatening clinical disorders may be amenable to treatment with a drug that can stimulate respiratory drive. These include acute respiratory failure secondary to chronic obstructive pulmonary disease, post-anesthetic respiratory depression, and apnea of prematurity. Doxapram has been available for over forty years for the treatment of these conditions and it has a low side effect profile compared to other available agents. Generally though, the use of doxapram has been limited to these clinical niches involving patients in the intensive care, post-anesthesia care and neonatal intensive care units. Recent basic science studies have made considerable progress in understanding the molecular mechanism of doxapram's respiratory stimulant action. Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing.

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