右美沙芬:n -甲基-d-天冬氨酸受体拮抗剂治疗疼痛的研究进展

Anita Siu, Richard Drachtman
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引用次数: 70

摘要

右美沙芬(DM)是一种非竞争性n -甲基-d-天冬氨酸(NMDA)受体拮抗剂,被广泛用作止咳药。DM还通过兴奋性氨基酸(EAAs)的非竞争性拮抗作用来防止神经元损伤和调节痛觉。已发现右美沙芬可用于治疗癌症患者的疼痛和甲氨蝶呤引起的神经毒性。本文对糖尿病在肿瘤患者中的临床研究进行综述。
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Dextromethorphan: A Review of N-methyl-d-aspartate Receptor Antagonist in the Management of Pain

Dextromethorphan (DM) is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, which is widely used as an antitussive agent. DM also prevents neuronal damage and modulates pain sensation via noncompetitive antagonism of excitatory amino acids (EAAs). DM has been found to be useful in the treatment of pain in cancer patients and in the treatment of methotrexate-induced neurotoxicity. Clinical studies with DM in cancer patients are reviewed in this article.

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