[细胞对压力的反应]。

Carmen Gómez Eichelmann
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引用次数: 0

摘要

环境变化引起细胞反应,其特征是基因表达和细胞生理的改变。这种改变使细胞能够生存并适应新的环境。目前对细胞应激反应的研究主要集中在基因表达模式(转录组、蛋白质组)的鉴定上。以及它们与应激下细胞所表现出的生化(代谢组)、结构和功能变化的关系。在“细胞对应激的反应”研讨会上,介绍了应激对细菌和真菌细胞功能的影响:1)大肠杆菌的营养应激和DNA损伤与诱变。2)营养和氧化应激对光念珠菌和亚端粒沉默的影响,3)冷应激对大肠杆菌和RNA降解的影响,4)氧化和热应激对大肠杆菌和差异蛋白合成的影响。
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[Cellular response to stress].

Environmental changes induce a cellular response characterized by a modification in the genetic expression and physiology of the cell. This modification allows the cell to survive and adapt to the new environment. Current studies on cellular stress response are mainly focused on the identification of the genetic expression patterns (transcriptome, proteome). and their relation with the biochemical (metabolome), structural and functional changes displayed by the cells under stress. In the symposium on Cellular Response to Stress, four works were presented about the stress effect on cellular functions of bacteria and fungi: 1) nutritional stress in Escherichia coli and DNA damage and mutagenesis. 2) nutritional and oxidative stress in Candida glabrata and subtelomeric silencing, 3) cold stress in E. coli and RNA degradation, and 4) oxidative and heat stress in E. coli and differential protein synthesis.

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