免疫衰老:老年人适应性免疫缺陷。

F T Hakim, R E Gress
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引用次数: 213

摘要

在临床上,衰老与传染病的频率和严重程度的增加以及癌症、慢性炎症性疾病和自身免疫的发病率增加有关。这些与年龄相关的免疫功能障碍是新生成naïve T淋巴细胞和B淋巴细胞以及记忆群体功能能力下降的结果。这些改变统称为免疫衰老。
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Immunosenescence: deficits in adaptive immunity in the elderly.

Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naïve T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

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Tissue antigens
Tissue antigens 医学-病理学
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