微反应器作为合成化学家手中的工具。

P H Seeberger, K Geyer, J D C Codée
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引用次数: 4

摘要

微反应装置的最新发展及其在化学许多不同领域的广泛应用表明,微反应器可能会对化学家进行实验的方式产生重大影响。反应小型化为合成有机化学家提供了许多优势:高通量扫描反应条件,精确控制反应变量,使用少量试剂,增加安全参数,并随时扩大合成过程。广泛的单相和多相反应已经在基于微流体的设备中进行。当然,微反应器还不能应用于所有的化学领域,微流体系统也有缺点。有限的反应时间范围,对沉淀产物的高灵敏度和分析挑战必须克服。概述了可用于化学合成的微流体装置,并讨论了一些具体的例子,主要来自我们的实验室,以说明微反应器的潜力。
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Microreactors as tools in the hands of synthetic chemists.

Recent developments in the construction of microstructured reaction devices and their wide-ranging applications in many different areas of chemistry suggest that microreactors may significantly impact the way chemists conduct experiments. Miniaturizing reactions offers many advantages for the synthetic organic chemist: high-throughput scanning of reaction conditions, precise control of reaction variables, the use of small quantities of reagents, increased safety parameters, and ready scale-up of synthetic procedures. A wide range of single and multiphase reactions has been performed in microfluidic-based devices. Certainly, microreactors cannot be applied to all chemistries yet and microfluidic systems also have disadvantages. Limited reaction time ranges, high sensitivity to precipitating products, and analytical challenges have to be overcome. An overview of microfluidic devices available for chemical synthesis is provided and some specific examples, mainly from our laboratory, are discussed to illustrate the potential of microreactors.

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