青蒿素——抗疟疾治疗的创新基石。

Thomas Kuhn, Ying Wang
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引用次数: 35

摘要

世界卫生组织(世卫组织)建议使用以青蒿素为基础的联合疗法来治疗特别是耐多药疟疾,因为目前使用的药物已变得越来越无效。本章综述了中药中青蒿素的发现及其在青蒿素类药物中的进一步发展。报告强调指出,如何建立了生产基于青蒿素的药物所需的自然产生的过氧化物青蒿素的复杂供应链;因此解决了显著的治疗需求和对药物的高要求。
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Artemisinin--an innovative cornerstone for anti-malaria therapy.

Artemisinin-based Combination Therapies (ACT) are recommended by the World Health Organization (WHO) to treat especially multidrug resistant forms of malaria, as currently used medications have become increasingly ineffective. In this chapter, the discovery of artemisinin from Traditional Chinese Medicine and its further development to ACT are reviewed. It is highlighted how the complex supply chain to the naturally occurring endoperoxide artemisinin, required to produce ACT-based drugs, was established; thus addressing the significant therapeutic needs and high demands for the medication.

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