Edmunds Lukevics, Edgars Abele, Pavel Arsenyan, Ramona Abele, Kira Rubina, Irina Shestakova, Ilona Domracheva, Violetta Vologdina
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Synthesis and cytotoxicity of silicon containing pyridine and quinoline sulfides.
Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.
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