Edgars Abele, Kira Rubina, Ramona Abele, Olegs Dzenitis, Pavel Arsenyan, Juris Popelis, Maris Veveris, Dainuvite Meirena, Edmunds Lukevics
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Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents.
Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
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