氯己定治疗牙周炎的龈下应用

Revue belge de medecine dentaire Pub Date : 2007-01-01
Jan Cosyn, H De Bruyn, M Moradi Sabzevar
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引用次数: 0

摘要

临床医生经常面临的治疗效果较差的刮除和根刨主要是在深袋和功能。为了优化这些弱反应部位的临床效果,已经开发和研究了化学机械治疗策略,其中使用氯己定作为抗菌剂。在这篇综述中,我们讨论了牙龈下洗必定冲洗、凝胶、贴片和清漆治疗牙周炎的临床效果。几乎没有证据表明使用氯己定溶液龈下冲洗会对治疗结果有利。此外,与水冷却相比,使用氯己定溶液作为(超声波)洗洁时的冷却剂在临床上并不会产生更好的反应。尽管凝胶的高粘度,它的使用不能证明在治疗牙周炎的临床效果也可以忽略不计。多中心研究表明,结合刮治和根治以及氯己定芯片治疗后,口袋缩小率和临床附着度显著提高。由于一些研究未能证实这一发现,因此需要更多的研究来阐明芯片的附加价值。牙龈下给予过饱和氯己定清漆似乎有希望作为附加的临床效果已被报道。然而,对这一治疗理念的大规模研究尚缺乏。临床医生应继续以机械手段为主治疗牙周炎。可以考虑在龈下给药氯己定的基础上进行补充化学治疗;然而,当除垢和根治效果变差时,溶液和凝胶不适合作为补偿性辅助。
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[Subgingival application of chlorhexidine in the treatment of periodontitis].

The clinician is frequently faced with poor treatment outcome of scaling and root planing predominantly in deep pockets and furcations. In an attempt to optimize clinical effects at these weakly responding sites chemo-mechanical treatment strategies have been developed and studied, among those using chlorhexidine as an antimicrobial agent. In this overview the clinical effects of subgingival chlorhexidine irrigation, gel, chip and varnish administration as an adjunct to scaling and root planing in the treatment of periodontitis are discussed. There is little to no evidence indicating treatment outcome will benefit from subgingival irrigation using chlorhexidine solutions. Furthermore, the use of a chlorhexidine solution as a coolant during (ultra)sonic scaling does not result in a clinically superior response when compared to water cooling. Despite the high viscosity of a gel, its use cannot be justified in the treatment of periodontitis as clinical effects are also negligible. Multi-center studies have indicated significantly higher pocket reductions and clinical attachment gains following a combination of scaling and root planing and the administration of a chlorhexidine chip. As some studies failed to confirm this finding, more research is needed to elucidate the additional value of the chip. The subgingival administration of a supersaturated chlorhexidine varnish seems promising as additive clinical effects have been reported. Large-scale studies are however lacking on this treatment concept. The clinician should continue treating periodontitis primarily by mechanical means. Supplemental chemical therapy based on subgingival chlorhexidine administration can be considered; yet, solutions and gels are not suitable as compensatory aids when scaling and root planing becomes less effective.

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