验证在碘浓度和物体外部测量的计算机断层扫描数之间使用校准因子来估计物体内部的碘浓度:模拟实验。

Radiation medicine Pub Date : 2008-05-01 Epub Date: 2008-05-29 DOI:10.1007/s11604-007-0220-9
Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi
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引用次数: 9

摘要

目的:本研究的目的是验证使用物体外部测量的校准因子来估计物体内部的碘浓度,以提高定量对比增强计算机断层扫描(CT)的准确性。材料和方法:将几种已知浓度(0、6、9和12 mg I/ml)的碘造影剂(CM)样品放置在两种尺寸的圆柱形丙烯酸模型内外,在不同的管电压和电流组合(kV/mAs-80/200、100/200、120/200、140/200)下成像,获得K因子。比较了幻影与管电压之间的K因子。每个CM浓度由CT数估计,使用在幻膜外测量的K因子。结果:K因子在不同影型和不同管电压间存在差异(P < 0.05)。虽然K因子在幻体不同区域间存在统计学上的显著差异,但平均变异系数为3% ~ 4%。估计浓度的平均误差为-5.5%。结论:利用体表测得的K因子,无论体表大小和管电压如何,均可准确估计患者体内区域的CM浓度。
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Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: phantom experiment.

Purpose: The aim of this study was to validate the use of a calibration factor measured outside the object for estimating the iodine concentration inside the object to improve the accuracy of the quantitative contrast-enhanced computed tomography (CT).

Materials and methods: Several known concentrations (0, 6, 9, and 12 mg I/ml) of iodine contrast material (CM) samples were placed inside and outside cylindrical acrylic phantoms of two sizes and were imaged under various combinations of the tube voltages and currents (kV/mAs-80/200, 100/200, 120/200, 140/200) to obtain K factors. The K factors were compared between the phantoms and among the tube voltages. Each CM concentration was estimated from the CT number using the K factor measured outside the phantom.

Results: The K factors varied between the phantoms or among the tube voltages (P < 0.05). Although there were statistically significant variations in K factors among the different regions in a phantom, the mean variation coefficient was 3%-4%. The mean error of the estimated concentration was -5.5%.

Conclusion: The CM concentration should be accurately estimated at the region within a patient's body using the K factor measured at the surface of the body regardless of body size and tube voltage.

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