EGR1在增生性皮肤病中作为差异表达基因的证据

IF 3.5 Q1 EDUCATION & EDUCATIONAL RESEARCH Genomic medicine Pub Date : 2007-01-01 Epub Date: 2007-07-25 DOI:10.1007/s11568-007-9010-9
Min Fang, Sue Ann Wee, Karyn Ronski, Hongran Fan, Shiying Tao, Qun Lin
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引用次数: 17

摘要

增生性表皮疾病的范围从良性增生如牛皮癣到基底细胞癌(BCC)和鳞状细胞癌(SCC),这是美国最常见的两种癌症。虽然它们都起源于表皮,但这些疾病在生物学行为上存在巨大差异,其潜在的基因表达模式尚未得到比较。因此,我们检查了这些疾病的mRNA转录水平,以识别和进一步表征差异表达基因。转录表达模式区分了这些疾病,并确定了EGR1和其他基因,其表皮表达在BCC和SCC中降低,但在牛皮癣中升高。Egr-1在体外抑制良性和恶性表皮细胞的生长,并抑制Cdc25A表达和Cdk2去磷酸化。这些数据表明基因表达谱可以区分表皮增生性疾病,并提示Egr-1可能在预防不受控制的表皮生长中发挥作用。
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Evidence of EGR1 as a differentially expressed gene among proliferative skin diseases.

Hyperproliferative epidermal disorders range from benign hyperplasias such as psoriasis to basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the two most common cancers in the US. While they all arise from the epidermis, these diseases differ dramatically in biological behavior and their underlying gene expression patterns have not been compared. We thus examined mRNA transcript levels in these disorders to identify and further characterize differentially expressed genes. Transcript expression patterns distinguish these disorders and identify EGR1, among other genes, whose epidermal expression is decreased in BCC and SCC but is elevated in psoriasis. Egr-1 inhibits growth of benign and malignant epidermal cells in vitro and appears to suppress both Cdc25A expression and Cdk2 dephosphorylation. These data indicate that gene expression profiling can differentiate epidermal hyperproliferative diseases and suggest that Egr-1 may play a role in preventing uncontrolled epidermal growth.

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