用更少的资源做更多的可用选择:实验室自动化作为武器库中的一个工具。

S Scypinski, J Baiano, T Sadlowski
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引用次数: 0

摘要

需要分析支持的项目可以从许多不同的情况演变而来,例如来自药物发现的新分子实体;过程的变化;包装的变更;网站的变化;线扩展;在许可的项目和化合物中。实验室自动化已被证明为协助分析发展提供了可行和实用的解决方案。然而,这并不总是最合乎逻辑的答案。当面对一个新项目时,一个真正灵活且响应迅速的分析单元将根据具体情况做出决定,是否最好:自动化所涉及的部分或所有方面/测试;外包给信誉良好并获认可的合约研究机构;雇佣临时助手;利用现有的内部资源;使用上述选项的组合(例如,评估新项目的复杂性与内部资源当前正在处理的内容)。本文讨论了各种方案在提供分析支持方面的优缺点,并提出了最有效利用资源的方案。强调了自动化作为这些选项库中重要工具之一的作用。
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Available options for doing more with less: laboraory automation as one tool in the arsenal.

Projects that require analytical support can evolve from a number of different situations, for example new molecular entities from drug discovery; process changes; packaging changes; site changes; line extensions; and inlicensed projects and compounds. Laboratory automation has been shown to provide a viable and practical solution to assisting in analytical development. However, it is not always the most logical answer. A truly flexible and responsive analytical unit will make a decision on a case-by-case basis, when faced with a new project, whether it is best to: automate some or all aspects/testing involved; contract out to a reputable and approved contract research organization (CRO); hire temporary help; use available in-house resources; use a combination of the options shown above (for example to evaluate the complexity of the new project versus what the in-house resources are currently working on). The paper discusses the advantages and disadvantages of the various options with respect to providing analytical support and suggests optionsfor the most effective use of resources. The role of automation as one of the important tools in the arsenal of these options is highlighted.

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