Giorgio Ciprandi, Catherine Klersy, Franco Ameli, Ignazio Cirillo
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引用次数: 18
摘要
背景:鼻流测量法测量的鼻腔气流在变应性鼻炎(AR)中经常受损。去充血试验评估应用鼻内血管收缩药物是否增加鼻腔气流。过敏的特征是炎症,而对去充血试验的反应与炎症反应的程度有关,这一点之前已经得到了证明。本研究的目的是验证使用视觉模拟量表(VASs)作为鼻压测量法在持续变应性鼻炎患者去充血试验评估中的适用性。方法:对103例患者进行研究,平均年龄23岁[2.24 SD]。对所有患者进行鼻部症状、VAS、鼻压测量和鼻充血测试。结果:去充血试验后,VAS与鼻气流有显著相关性(Spearman R = -33.3%;P < 0.001)。此外,检测到疏通措施变化之间存在显著的负相关,Spearman R = -64.7% (p < 0.001)。相关敏感性为92.5%,特异性为60.0%。受试者工作特征曲线下相应面积为0.81。结论:使用VAS评估去充血测试似乎与临床相关,因为它允许在没有鼻压测量的情况下以相当程度的可靠性进行这样的测试。
Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis.
Background: Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. That allergy is characterized by inflammation and that the response to the decongestion test correlates with the grade of inflammatory reaction has previously been shown. The aim of this study was to verify the suitability of the use of the visual analog scales (VASs) as a surrogate for rhinomanometry in the decongestion test assessment in patients with persistent allergic rhinitis.
Methods: One hundred three patients (mean age, 23 years [2.24 SD]) were studied. Nasal symptoms, VAS, rhinomanometry, and nasal decongestion test were assessed in all patients.
Results: A significant association was observed between VAS and nasal airflow after the decongestion test (Spearman R = -33.3%; p < 0.001). Moreover, a significant inverse association between changes in decongestion measures was detected, with a Spearman R = -64.7% (p < 0.001). The associated sensitivity was of 92.5%, and the specificity for this test was 60.0%. The corresponding area under the receiver operating characteristic curve was 0.81.
Conclusion: The use of VAS for assessing the decongestion test appears clinically relevant in that it allows, with a fair degree of reliability, such a test to be performed in the absence of rhinomanometry.