{"title":"他克莫司在高危异体角膜移植中的疗效。","authors":"F Nilüfer Yalçindag, Osman Incel, Ozden Ozdemir","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We evaluated the efficacy and safety of tacrolimus in prevention of allograft rejection in high-risk allo-limbal grafts. Six eyes of six patients with severe limbal stem cell deficiency were included. All patients were started 0.1 mg x kg 1 x day(-1) tacrolimus orally 3 days before the surgery. Limbal allo-graft transplantation for ocular surface reconstruction had a successful outcome with using systemic tacrolimus for immunosuppression.</p>","PeriodicalId":8070,"journal":{"name":"Annals of ophthalmology","volume":"40 3-4","pages":"152-6"},"PeriodicalIF":0.0000,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of tacrolimus in high-risk limbal allo-graft transplantation.\",\"authors\":\"F Nilüfer Yalçindag, Osman Incel, Ozden Ozdemir\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We evaluated the efficacy and safety of tacrolimus in prevention of allograft rejection in high-risk allo-limbal grafts. Six eyes of six patients with severe limbal stem cell deficiency were included. All patients were started 0.1 mg x kg 1 x day(-1) tacrolimus orally 3 days before the surgery. Limbal allo-graft transplantation for ocular surface reconstruction had a successful outcome with using systemic tacrolimus for immunosuppression.</p>\",\"PeriodicalId\":8070,\"journal\":{\"name\":\"Annals of ophthalmology\",\"volume\":\"40 3-4\",\"pages\":\"152-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of ophthalmology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
我们评估了他克莫司预防高风险同种异体角膜移植排斥反应的有效性和安全性。包括6例严重角膜缘干细胞缺乏症患者的6只眼。所有患者在手术前3天开始口服他克莫司0.1 mg x kg 1 x day(-1)。同种异体角膜缘移植用于眼表重建与全身他克莫司免疫抑制成功的结果。
Effectiveness of tacrolimus in high-risk limbal allo-graft transplantation.
We evaluated the efficacy and safety of tacrolimus in prevention of allograft rejection in high-risk allo-limbal grafts. Six eyes of six patients with severe limbal stem cell deficiency were included. All patients were started 0.1 mg x kg 1 x day(-1) tacrolimus orally 3 days before the surgery. Limbal allo-graft transplantation for ocular surface reconstruction had a successful outcome with using systemic tacrolimus for immunosuppression.