初级嗅觉网络刺激间歇性的对比增强及其行为意义。

Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-02-20 DOI:10.1186/jbiol120
Hong Lei, Jeffrey A Riffell, Stephanie L Gage, John G Hildebrand
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引用次数: 74

摘要

背景:动物导航到一个看不见的气味源必须准确地解决刺激的时空分布,以表达适当的逆风飞行行为。由空气湍流引起的自然气味羽流的间歇性对许多昆虫来说是至关重要的,包括飞蛾,Manduca sexta,对气味源的气味调节搜索行为。当飞蛾的触角受到间歇性的气味刺激时,初级嗅觉中心(触角叶)的投射神经元(PNs)(类似于脊椎动物的嗅球)产生离散的动作电位爆发,这些动作电位爆发被抑制期分开,这表明PNs可能使用二元爆发/非爆发的神经模式来解决和增强气味羽流中遇到的间歇性刺激。结果:我们首先验证了这一假设,建立了二甲库兰可靠和可逆地破坏PNs产生爆炸反应模式的能力。反过来,行为学研究表明,将这种药物以生理实验中使用的有效浓度注射到触角叶后,即使动物已经检测到气味信号,也不能再有效地定位气味来源。结论:我们的研究结果建立了PNs的爆发反应模式与蛾的气味追踪行为之间的直接联系,证明了在触角叶回路中解决自然气味刺激动力学的行为意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Contrast enhancement of stimulus intermittency in a primary olfactory network and its behavioral significance.

Background: An animal navigating to an unseen odor source must accurately resolve the spatiotemporal distribution of that stimulus in order to express appropriate upwind flight behavior. Intermittency of natural odor plumes, caused by air turbulence, is critically important for many insects, including the hawkmoth, Manduca sexta, for odor-modulated search behavior to an odor source. When a moth's antennae receive intermittent odor stimulation, the projection neurons (PNs) in the primary olfactory centers (the antennal lobes), which are analogous to the olfactory bulbs of vertebrates, generate discrete bursts of action potentials separated by periods of inhibition, suggesting that the PNs may use the binary burst/non-burst neural patterns to resolve and enhance the intermittency of the stimulus encountered in the odor plume.

Results: We tested this hypothesis first by establishing that bicuculline methiodide reliably and reversibly disrupted the ability of PNs to produce bursting response patterns. Behavioral studies, in turn, demonstrated that after injecting this drug into the antennal lobe at the effective concentration used in the physiological experiments animals could no longer efficiently locate the odor source, even though they had detected the odor signal.

Conclusions: Our results establish a direct link between the bursting response pattern of PNs and the odor-tracking behavior of the moth, demonstrating the behavioral significance of resolving the dynamics of a natural odor stimulus in antennal lobe circuits.

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