地塞米松对晶状体上皮细胞成纤维细胞生长因子受体的异常表达:糖皮质激素诱导的后囊膜下白内障的意义。

Annals of ophthalmology Pub Date : 2009-01-01

Baichuan Wang, Chunlin Chen, Xiaolei Yin, Xiaofan Chen, Jian Ye

{"title":"地塞米松对晶状体上皮细胞成纤维细胞生长因子受体的异常表达:糖皮质激素诱导的后囊膜下白内障的意义。","authors":"Baichuan Wang, Chunlin Chen, Xiaolei Yin, Xiaofan Chen, Jian Ye","doi":"","DOIUrl":null,"url":null,"abstract":"We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.","PeriodicalId":8070,"journal":{"name":"Annals of ophthalmology","volume":"41 1","pages":"31-9"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abnormal expression of fibroblast growth factor receptor on lens epithelial cells by dexamethasone: implications for glucocorticoid-induced posterior subcapsular cataract.\",\"authors\":\"Baichuan Wang, Chunlin Chen, Xiaolei Yin, Xiaofan Chen, Jian Ye\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.\",\"PeriodicalId\":8070,\"journal\":{\"name\":\"Annals of ophthalmology\",\"volume\":\"41 1\",\"pages\":\"31-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of ophthalmology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

我们研究了糖皮质激素诱导大鼠晶状体上皮细胞(LECs)中AqH中bFGF、FGFR和β -晶体蛋白的改变。结果。数据显示，地塞米松对AqH中的bFGF没有影响，但会降低LECs中的FGFR1。治疗6个月后，4/12晶状体后囊膜下检测到细胞。体外观察显示FGFR1或β -结晶蛋白被地塞米松下调。LECs中的FGFR可能在糖皮质激素诱导的PSC形成中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Abnormal expression of fibroblast growth factor receptor on lens epithelial cells by dexamethasone: implications for glucocorticoid-induced posterior subcapsular cataract.

We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annals of ophthalmology 医学-眼科学

自引率

0.00%

发文量

期刊最新文献

Silent sinus syndrome. Examination Under Anesthesia Exfoliation Syndrome Editorial: Year end wrap-up. New femtosecond laser technology applications in corneal lamellar surgery.