靶向GVHD的间充质干细胞。

Liang Wang, Robert ChunHua Zhao
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引用次数: 14

摘要

急性移植物抗宿主病(GVHD)发生在同种异体造血干细胞移植后,是供体免疫细胞对宿主组织的反应。大约35%-50%的造血干细胞移植(HSCT)受者会发展为急性GVHD。它与相当高的发病率和死亡率有关,特别是对通常由糖皮质激素(类固醇)组成的初级治疗无反应的患者。大多数可用的二线和三线治疗类固醇难治性急性GVHD诱导严重免疫缺陷,这通常伴随着致命的感染并发症。间充质干细胞(MSCs)已被证明具有介导免疫调节作用。最近阐明的间充质干细胞的免疫抑制潜力为其作为细胞免疫抑制剂的临床试验奠定了基础,间充质干细胞已被用于治疗类固醇难治性急性GVHD患者,并在许多研究中获得了令人鼓舞的反应。间充质干细胞在治疗GVHD方面的作用越来越明显。
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Mesenchymal stem cells targeting the GVHD.

Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. About 35%-50% of hematopoietic stem cell transplant (HSCT) recipients will develop acute GVHD. It is associated with considerable morbidity and mortality, particularly in patients who do not respond to primary therapy, which usually consists of glucocorticoids(steroids). Most of the available second-line and third-line treatments for steroid-refractory acute GVHD induce severe immunodeficiency, which is commonly accompanied by lethal infectious complications. Mesenchymal stem cells (MSCs) have been shown to mediate immunomodulatory effects. The recently elucidated immunosuppressive potential of mesenchymal stem cells has set the stage for their clinical testing as cellular immunosuppressants, MSCs have been used in patients with steroid-refractory acute GVHD, and encouraging responses have been obtained in many studies. The utility of MSCs for the treatment of GVHD is becoming clear.

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