2'，5'-脱氧-5'-苯丙基腺苷类似物的合成及抗hcv活性研究

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp052

Masahiro Ikejiri, Takayuki Ohshima, Akemi Fukushima, Kunitada Shimotohno, Tokumi Maruyama

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引用次数: 0

摘要

合成了几种含有亚甲基而非5′-O原子的核苷类似物，研究了核苷类似物的5′修饰对其抗hcv活性的影响。在这些类似物中，5'-phenacyl类似物具有良好的抗hcv活性，EC(50)为15.1 muM。该化合物被假设通过一种不涉及传统5'- o -三磷酸化过程的新型机制起作用。

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Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs.

Several nucleoside analogs containing a methylene group instead of a 5'-O atom were synthesized to study the effect of the 5'-modification of nucleoside analogs on their anti-HCV activity. Among the analogs, a 5'-phenacyl analog exhibited good anti-HCV activity with an EC(50) of 15.1 muM. This compound is hypothesized to function via a novel type of mechanism that does not involve the conventional 5'-O-triphosphorylation process.

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Nucleic acids symposium series (2004)

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