9-(2- c -氰-2-脱氧- β -d -阿拉伯-戊呋喃基)鸟嘌呤，一种潜在的抗卡波西肉瘤相关疱疹病毒感染b淋巴瘤的抗肿瘤药物。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp048

Satoshi Ichikawa, Masaki Otawa, Yasuhiro Teishikata, Koji Yamada, Masahiro Fujimuro, Hideyoshi Yokosawa, Akira Matsuda

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引用次数: 2

摘要

研究了几种9-(2- c -氰-2-脱氧-l- β -d -阿拉伯戊呋喃基)嘌呤衍生物对卡波西肉瘤相关疱疹病毒(KSHV)感染的原发性积液淋巴瘤(PEL)细胞的抑制作用。鸟嘌呤衍生物(2、CNDAG)以及2-氨基-6-取代嘌呤衍生物3、4和5抑制kshv阳性细胞的生长，但在>15 muM浓度下对kshv阴性细胞无细胞毒性。因此，化合物2、3、4和5对感染KSHV的PEL细胞具有选择性细胞毒性。

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9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

Several 9-(2-C-cyano-2-deoxy-l-beta-D-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (2, CNDAG) as well as the 2-amino-6-substituted-purine derivatives 3, 4 and 5 inhibited KSHV-positive cell growth but showed no cytotoxicity against KSHV-negative cells at >15 muM concentrations. Therefore, it was found that compounds 2, 3, 4 and 5 showed selective cytotoxicity against PEL cells infected with KSHV.

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Nucleic acids symposium series (2004)

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