致编辑的信:dicer表达是否影响shRNA的加工?

Gene regulation and systems biology Pub Date : 2009-06-19 DOI:10.4137/grsb.s2551

Neil Senzer, Donald Rao, John Nemunaitis

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引用次数: 1

摘要

Dicer和Drosha mRNA水平升高已被许多研究人员记录在一系列肿瘤类型(包括卵巢癌)中，但与患者生存没有任何明显的相关性，也没有证据表明shRNA加工受到干扰。Merritt等人(NEJM 359(25):2641- 50,2008)最近发表的一篇文章报道了他们在卵巢癌患者中的发现，得出了相反的结论。解决这个问题需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Letter to the editor: Does dicer expression affect shRNA processing?

Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue.

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Gene regulation and systems biology

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