Georgios D Mitsis, Rong Zhang, Benjamin D Levine, Efthalia Tzanalaridou, Demosthenes G Katritsis, Vasilis Z Marmarelis
{"title":"自主神经控制脑血流动力学。","authors":"Georgios D Mitsis, Rong Zhang, Benjamin D Levine, Efthalia Tzanalaridou, Demosthenes G Katritsis, Vasilis Z Marmarelis","doi":"10.1109/MEMB.2009.934908","DOIUrl":null,"url":null,"abstract":"<p><p>Despite the rich innervation of the cerebral vasculature by both sympathetic and parasympathetic nerves, the role of autonomic control in cerebral circulation and, particularly, cerebral hemodynamics is not entirely clear. Previous animal studies have reported inconsistent results regarding the effects of electrical stimulation or denervation on cerebral blood flow (CBF), cerebral pressure-flow relationship, and cerebral vessel response to metabolic stimuli. Moreover, with the advance of transcranial Doppler ultrasound (TCD), which yields accurate measurements of CBF velocity (CBFV) with high time resolution, it has been found that in humans CBFV in the middle cerebral artery decreased substantially during lower body negative pressure (LBNP) and head-up tilt in the absence of systemic hypotension, which suggests the presence of cerebral vasoconstriction associated with augmented sympathetic nerve activity during orthostatic stress. These observations were based on assessing static measures of cerebral circulation, i.e., mean values of artevial blood pressure (ABP) and CBF with a low time resolution.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934908","citationCount":"37","resultStr":"{\"title\":\"Autonomic neural control of cerebral hemodynamics.\",\"authors\":\"Georgios D Mitsis, Rong Zhang, Benjamin D Levine, Efthalia Tzanalaridou, Demosthenes G Katritsis, Vasilis Z Marmarelis\",\"doi\":\"10.1109/MEMB.2009.934908\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Despite the rich innervation of the cerebral vasculature by both sympathetic and parasympathetic nerves, the role of autonomic control in cerebral circulation and, particularly, cerebral hemodynamics is not entirely clear. Previous animal studies have reported inconsistent results regarding the effects of electrical stimulation or denervation on cerebral blood flow (CBF), cerebral pressure-flow relationship, and cerebral vessel response to metabolic stimuli. Moreover, with the advance of transcranial Doppler ultrasound (TCD), which yields accurate measurements of CBF velocity (CBFV) with high time resolution, it has been found that in humans CBFV in the middle cerebral artery decreased substantially during lower body negative pressure (LBNP) and head-up tilt in the absence of systemic hypotension, which suggests the presence of cerebral vasoconstriction associated with augmented sympathetic nerve activity during orthostatic stress. These observations were based on assessing static measures of cerebral circulation, i.e., mean values of artevial blood pressure (ABP) and CBF with a low time resolution.</p>\",\"PeriodicalId\":50391,\"journal\":{\"name\":\"IEEE Engineering in Medicine and Biology Magazine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1109/MEMB.2009.934908\",\"citationCount\":\"37\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Engineering in Medicine and Biology Magazine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/MEMB.2009.934908\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Engineering in Medicine and Biology Magazine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MEMB.2009.934908","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Autonomic neural control of cerebral hemodynamics.
Despite the rich innervation of the cerebral vasculature by both sympathetic and parasympathetic nerves, the role of autonomic control in cerebral circulation and, particularly, cerebral hemodynamics is not entirely clear. Previous animal studies have reported inconsistent results regarding the effects of electrical stimulation or denervation on cerebral blood flow (CBF), cerebral pressure-flow relationship, and cerebral vessel response to metabolic stimuli. Moreover, with the advance of transcranial Doppler ultrasound (TCD), which yields accurate measurements of CBF velocity (CBFV) with high time resolution, it has been found that in humans CBFV in the middle cerebral artery decreased substantially during lower body negative pressure (LBNP) and head-up tilt in the absence of systemic hypotension, which suggests the presence of cerebral vasoconstriction associated with augmented sympathetic nerve activity during orthostatic stress. These observations were based on assessing static measures of cerebral circulation, i.e., mean values of artevial blood pressure (ABP) and CBF with a low time resolution.