Jan J Zebrowski, Pawel Kuklik, Teodor Buchner, Rafał Baranowski
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引用次数: 1
摘要
本文介绍了心房与窦房结(SA)和房室结(AV)的一维(1-D)模型。这两个节点分别由15个单元的扩散耦合的改进van der Pol振荡器链来建模,而心房组织则由一个90个单元的扩散耦合fitzhuh - nagumo (FHN)方程链来表示。改进的范德波尔振荡器能够再现重要的生理特性,如折射周期、相敏特性和动作电位频率的变化模式。自主神经系统的两个分支的活动可以以一种简化的方式引入模型。该模型能够研究节点动作电位传导率的大小对峰间间隔的影响。相当于RR间期),并解释了某些患者RR间期交替的发生。呼吸调节心率和单次深呼吸的效果也可以建模。最后,研究了心房的隐蔽传导效应,得出的结果与记录的心率变异性数据相当。
A one-dimensional (1-D) model of the atrium together with the sinoatrial (SA) and atrioventricular (AV) nodes is presented in this article. The two nodes are each modeled by 15-element, diffusively coupled, modified van der Pol oscillator chains, while the atrium tissue is represented by a 90-element chain of diffusively coupled FitzHugh-Nagumo (FHN) equations. The modified van der Pol oscillators are able to reproduce physiologically important properties, such as the refraction period, phase-sensitivity properties, and modes of change of the action potential frequency. The activity of both branches of the autonomous nervous system may be introduced into the model in a simplified way. The model enables the study of the effect of the magnitude of the action potential conduction rate in the nodes on interspike intervals (ISIs; equivalent of RR intervals) and explains the occurrence of RR-interval alternans in certain patients. The effect of breathing modulation of heart rate and of a single deep breath can also be modeled. Finally, concealed conduction effects in the atrium are studied, yielding results comparable with recorded heart rate variability data.