胚胎脊髓组织移植促进大鼠坐骨神经再生。

Ge Xiong, Noriyuki Ozaki, Yasuo Sugiura
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引用次数: 13

摘要

以大鼠坐骨神经为实验对象,研究了胚胎脊髓组织移植对宿主运动神经再生和靶肌再神经支配的影响。观察移植组、吻合不移植组和naïve组动物的肌电反应、靶肌运动终板(MEP)数量、神经轴突数量和逆行标记运动神经元数量。移植组肌电图在第8周恢复正常,而吻合组肌电图未恢复正常。移植组MEP计数明显高于吻合组。移植组有髓轴突计数和髓鞘厚度明显高于吻合组。移植组逆行标记运动神经元数量明显增多。我们认为胚胎脊髓组织移植可以促进宿主运动神经再生和靶肌肉神经再生。
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Transplanted embryonic spinal tissue promotes severed sciatic nerve regeneration in rats.

The effects of transplanted embryonic spinal tissue on host motor nerve regeneration and target muscle reinervation were investigated in severed sciatic nerves of rats. The electromyogram (EMG) responses and number of motor end plates (MEP) in target muscles, number of nerve axons, and retrogradely labeled motor neurons were examined in transplantation-, anastomosis without transplantation-, and naïve groups of the animals. The EMG patterns of the transplantation group returned to nearly normal at the 8th week, but those of the anastomosis group did not. MEP counts in the transplantation group were significantly higher than in the anastomosis group. The myelinated axon counts and myelin sheath thickness in the transplantation group were significantly higher than those in the anastomosis group. The number of retrogradely labeled motor neurons was significantly higher in the transplantation group. We conclude that transplanted embryonic spinal tissue can promote both host motor nerve regeneration and target muscle reinnervation.

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来源期刊
Archives of histology and cytology
Archives of histology and cytology 生物-细胞生物学
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期刊介绍: The Archives of Histology and Cytology provides prompt publication in English of original works on the histology and histochemistry of man and animals. The articles published are in principle restricted to studies on vertebrates, but investigations using invertebrates may be accepted when the intention and results present issues of common interest to vertebrate researchers. Pathological studies may also be accepted, if the observations and interpretations are deemed to contribute toward increasing knowledge of the normal features of the cells or tissues concerned. This journal will also publish reviews offering evaluations and critical interpretations of recent studies and theories.
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