酵母核小体定位中DNA分子内相互作用的评价。

Genome informatics. International Conference on Genome Informatics Pub Date : 2009-10-01

Michael Fernandez, Satoshi Fujii, Hidetoshi Kono, Akinori Sarai

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引用次数: 0

摘要

我们通过在核小体的晶体结构周围穿线DNA序列来计算DNA的分子内相互作用能。二核苷酸的分子内能量振荡频率约为10 bps，与先前的核小体模型一致。沿酵母基因组计算的分子内能量与实验测量的核小体定位呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of DNA intramolecular interactions for nucleosome positioning in yeast.

We calculated intramolecular interaction energies of DNA by threading DNA sequences around crystal structures of nucleosomes. The strength of the intramolecular energy oscillations at frequency approximately 10 bps for dinucleotides was in agreement with previous nucleosome models. The intramolecular energy calculated along yeast genome positively correlated with nucleosome positioning experimentally measured.

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Genome informatics. International Conference on Genome Informatics

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