病毒是否利用载体穿透粘液屏障?

Katharina Ribbeck
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引用次数: 3

摘要

我提出了一种病毒成功感染新个体的机制,尽管病毒是不动的粒子,没有定向运动的能力。在细胞内,病毒颗粒的运动是由马达和细胞骨架的元素引导的,但病毒如何穿过细胞外屏障,如粘液,仍然是一个谜。我认为病毒通过搭上细菌或精子细胞的便车来跨越这些屏障,这些细菌或精子细胞可以将自己运输到粘膜层,粘膜层的设计是为了保护底层细胞免受病原体的攻击。这一假设的一个重要含义是,阻断病毒与细菌或精子之间相互作用的药物可能是预防疾病的新工具。
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Do viruses use vectors to penetrate mucus barriers?

I propose a mechanism by which viruses successfully infect new individuals, despite being immotile particles with no ability for directed movement. Within cells, viral particle movements are directed by motors and elements of the cytoskeleton, but how viruses cross extracellular barriers, like mucus, remains a mystery. I propose that viruses cross these barriers by hitch-hiking on bacteria or sperm cells which can transport themselves across mucosal layers designed to protect the underlying cells from pathogen attack. An important implication of this hypothesis is that agents that block interactions between viruses and bacteria or sperm may be new tools for disease prevention.

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