{"title":"青光眼手术中丝裂霉素C的角膜并发症。","authors":"G Coppens, P Maudgal","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To report corneal toxicity of Mitomycin C application during filtering glaucoma surgery in two patients.</p><p><strong>Case reports: </strong>An elderly woman, 81 years of age, developed diffuse corneal epitheliopathy with subepithelial stromal oedema seven weeks after a trabeculectomy with Mitomycin C application. Another patient, a 76-year-old man, first developed a central epithelium defect and stromal oedema in the second postoperative week after a similar procedure. Later the corneal stroma melted, what resulted in perforation in the second postoperative month.</p><p><strong>Results: </strong>Intraoperative Mitomycin C application during trabeculectomy induced serious corneal complications several weeks after the surgery.</p><p><strong>Conclusions: </strong>Although infrequent, serious corneal complications may arise following the intraoperative use of Mitomycin C in filtering surgery for glaucoma. The possible contributing factors to the development of the corneal toxicity will be discussed.</p>","PeriodicalId":9308,"journal":{"name":"Bulletin de la Societe belge d'ophtalmologie","volume":" 314","pages":"19-23"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Corneal complications of intraoperative Mitomycin C in glaucoma surgery.\",\"authors\":\"G Coppens, P Maudgal\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To report corneal toxicity of Mitomycin C application during filtering glaucoma surgery in two patients.</p><p><strong>Case reports: </strong>An elderly woman, 81 years of age, developed diffuse corneal epitheliopathy with subepithelial stromal oedema seven weeks after a trabeculectomy with Mitomycin C application. Another patient, a 76-year-old man, first developed a central epithelium defect and stromal oedema in the second postoperative week after a similar procedure. Later the corneal stroma melted, what resulted in perforation in the second postoperative month.</p><p><strong>Results: </strong>Intraoperative Mitomycin C application during trabeculectomy induced serious corneal complications several weeks after the surgery.</p><p><strong>Conclusions: </strong>Although infrequent, serious corneal complications may arise following the intraoperative use of Mitomycin C in filtering surgery for glaucoma. The possible contributing factors to the development of the corneal toxicity will be discussed.</p>\",\"PeriodicalId\":9308,\"journal\":{\"name\":\"Bulletin de la Societe belge d'ophtalmologie\",\"volume\":\" 314\",\"pages\":\"19-23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin de la Societe belge d'ophtalmologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin de la Societe belge d'ophtalmologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Corneal complications of intraoperative Mitomycin C in glaucoma surgery.
Purpose: To report corneal toxicity of Mitomycin C application during filtering glaucoma surgery in two patients.
Case reports: An elderly woman, 81 years of age, developed diffuse corneal epitheliopathy with subepithelial stromal oedema seven weeks after a trabeculectomy with Mitomycin C application. Another patient, a 76-year-old man, first developed a central epithelium defect and stromal oedema in the second postoperative week after a similar procedure. Later the corneal stroma melted, what resulted in perforation in the second postoperative month.
Results: Intraoperative Mitomycin C application during trabeculectomy induced serious corneal complications several weeks after the surgery.
Conclusions: Although infrequent, serious corneal complications may arise following the intraoperative use of Mitomycin C in filtering surgery for glaucoma. The possible contributing factors to the development of the corneal toxicity will be discussed.