Veli-Matti Leinonen, Juha Varis, Risto Vesalainen, Johanna Päivärinta, Minna Sillanpää, Ilkka Kantola
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Office BP was measured twice with a 2-min interval after at least a 10-min rest using an ordinary sphygmomanometer.</p><p><strong>Results: </strong>Patients receiving ASA (n = 246) showed lower diastolic BP (83.9 ± 9.0 vs. 87.0 ± 9.6 mmHg; P < 0.001) compared with those who were not using any NSAIDs (n = 659). No significant difference in systolic BP was observed between the groups. As a result, pulse pressure was slightly higher in the ASA group (66.9 ± 18.9 vs. 63.3 ± 17.7 mmHg, P = 0.01). Mean arterial pressure was lower in the ASA group (106.2 ± 10.6 vs. 108.1 ± 10.4 mmHg, P = 0.02). In a stepwise linear multivariate model, ASA remained a significant predictor of lower diastolic BP even after the adjustment with the confounding effects of age and sex.</p><p><strong>Conclusion: </strong>According to our population-based study low-dose ASA does not have deleterious effects on BP control in drug-treated hypertensive patients.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32833ace3a","citationCount":"6","resultStr":"{\"title\":\"Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients.\",\"authors\":\"Veli-Matti Leinonen, Juha Varis, Risto Vesalainen, Johanna Päivärinta, Minna Sillanpää, Ilkka Kantola\",\"doi\":\"10.1097/HJR.0b013e32833ace3a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase blood pressure (BP) and potentially reduce the efficacy of several antihypertensive drugs. 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引用次数: 6
摘要
背景:非甾体抗炎药(NSAIDs)可能升高血压(BP),并可能降低几种降压药物的疗效。我们评估了低剂量乙酰水杨酸(ASA)对初级保健人群中药物治疗的高血压患者血压控制的影响。设计/方法:研究了来自芬兰西南部15个卫生中心的95名年龄在25-91岁(平均65.5岁)的连续患者。单药降压占45.7%,联合降压占54.3%。在休息至少10分钟后,使用普通血压计测量办公室血压两次,每次间隔2分钟。结果:接受ASA治疗的患者(n = 246)舒张压降低(83.9±9.0 vs 87.0±9.6 mmHg);结论:根据我们基于人群的研究,低剂量ASA对药物治疗的高血压患者的血压控制没有有害影响。
Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients.
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase blood pressure (BP) and potentially reduce the efficacy of several antihypertensive drugs. We evaluated the effect of low-dose acetylsalicylic acid (ASA) on BP control in drug-treated hypertensive patients in a primary care population.
Design/methods: Nine hundred and five successive patients aged 25–91 years (mean 65.5 years) from 15 health centers in south-west Finland were studied. The patients were on antihypertensive monotherapy (45.7%) or on combination therapy (54.3%). Office BP was measured twice with a 2-min interval after at least a 10-min rest using an ordinary sphygmomanometer.
Results: Patients receiving ASA (n = 246) showed lower diastolic BP (83.9 ± 9.0 vs. 87.0 ± 9.6 mmHg; P < 0.001) compared with those who were not using any NSAIDs (n = 659). No significant difference in systolic BP was observed between the groups. As a result, pulse pressure was slightly higher in the ASA group (66.9 ± 18.9 vs. 63.3 ± 17.7 mmHg, P = 0.01). Mean arterial pressure was lower in the ASA group (106.2 ± 10.6 vs. 108.1 ± 10.4 mmHg, P = 0.02). In a stepwise linear multivariate model, ASA remained a significant predictor of lower diastolic BP even after the adjustment with the confounding effects of age and sex.
Conclusion: According to our population-based study low-dose ASA does not have deleterious effects on BP control in drug-treated hypertensive patients.