[HLA- g:一种免疫调节非经典I类HLA分子]。

H Ksouri, R Bardi, F Mellouli, M Bejaoui
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引用次数: 0

摘要

HLA- g是一种特殊的非经典HLA I类分子。尽管其组织限制性表达和低多态性,该分子在先天和适应性免疫中发挥重要作用。HLA-G的耐受性使其成为一种在受孕早期起作用的免疫调节分子,保护胎儿组织免受母体免疫系统的侵害。本文就HLA-G的免疫调节功能及其与某些病理状态的关系作一综述。因此,少量的可溶性HLA-G或这种分子的特定等位基因表达与一些妊娠并发症有关。HLA-G在肿瘤细胞上的表达,通过细胞吞噬机制和调节性T细胞诱导来阻止抗肿瘤反应,与某些肿瘤类型的侵袭性和临床演变有关。HLA-G还参与保护移植组织免受排斥反应。揭示这种分子的新的更功能的同型异构体为更好地理解HLA-G的临床和生物学作用提供了新的见解。
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[HLA-G: an immunoregulatory non classical class I HLA molecule].

HLA-G is a particular non classical HLA class I molecule. Despite its tissue-restricted expression and low polymorphism, this molecule plays an important role in innate and adaptative immunity. The tolerogenic propriety of HLA-G makes it an immunomodulatory molecule acting in the early phases of conception, protecting fetal tissues from the maternal immune system. Immunomodulatory functions of HLA-G and the associations of this molecule with some pathological states are reported in this review. So, little amounts of soluble HLA-G or particular allelic expression of this molecule are associated with some pregnancy complications. HLA-G expression on tumor cells by preventing antitumor responses via a trogocytosis mechanism and regulatory T cells induction is associated with invasiveness and clinical evolution of some tumor types. HLA-G is also involved in the protection of the transplanted tissues from rejection. Revealing of new more functional homomultimeric isoforms of this molecule offers new insight in a better understanding of clinical and biological role of HLA-G.

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