{"title":"统计运动单元数估计和ALS试验:运动单元不稳定性的影响。","authors":"Jeremy M Shefner","doi":"10.1016/s1567-424x(08)00013-5","DOIUrl":null,"url":null,"abstract":"<p><p>Although statistical MUNE has many positive attributes, it is inappropriate for use in multicenter ALS clinical trials. No other commonly used technique for MUNE possesses all the attributes necessary to be a valid and useful outcome measure in ALS trials. However, MUNE as a theoretical outcome measure remains extremely attractive and new techniques must be sought so that it can reach its full potential as a valid and reproducible outcome measure in ALS clinical trials.</p>","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"135-41"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00013-5","citationCount":"12","resultStr":"{\"title\":\"Statistical motor unit number estimation and ALS trials: the effect of motor unit instability.\",\"authors\":\"Jeremy M Shefner\",\"doi\":\"10.1016/s1567-424x(08)00013-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Although statistical MUNE has many positive attributes, it is inappropriate for use in multicenter ALS clinical trials. No other commonly used technique for MUNE possesses all the attributes necessary to be a valid and useful outcome measure in ALS trials. However, MUNE as a theoretical outcome measure remains extremely attractive and new techniques must be sought so that it can reach its full potential as a valid and reproducible outcome measure in ALS clinical trials.</p>\",\"PeriodicalId\":85606,\"journal\":{\"name\":\"Supplements to Clinical neurophysiology\",\"volume\":\"60 \",\"pages\":\"135-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00013-5\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Supplements to Clinical neurophysiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/s1567-424x(08)00013-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Supplements to Clinical neurophysiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/s1567-424x(08)00013-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Statistical motor unit number estimation and ALS trials: the effect of motor unit instability.
Although statistical MUNE has many positive attributes, it is inappropriate for use in multicenter ALS clinical trials. No other commonly used technique for MUNE possesses all the attributes necessary to be a valid and useful outcome measure in ALS trials. However, MUNE as a theoretical outcome measure remains extremely attractive and new techniques must be sought so that it can reach its full potential as a valid and reproducible outcome measure in ALS clinical trials.
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