KP-1461:一种悬而未决的新型抗hiv药物?

David Evans
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引用次数: 0

摘要

一种实验性药物从实验室到美国食品和药物管理局(FDA)的批准通常是漫长、艰难和不确定的。对于一种颠覆常识的药物来说尤其如此。以西雅图Koronis制药公司的一种新型抗逆转录病毒药物KP-1461为例。目前所有被批准的抗艾滋病毒药物都旨在通过阻断病毒复制来减少体内病毒的数量,而KP-1461的设计目的不是抑制病毒复制,而是迫使新产生的艾滋病毒变得不那么容易感染人体细胞。
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KP-1461: a novel anti-HIV drug in limbo?

The path of an experimental drug from the laboratory to U.S. Food and Drug Administration (FDA) approval is typically long, rocky, and uncertain. It is especially so for a drug that turns common wisdom on its head. Take KP-1461, a new type of antiretroviral drug from Koronis Pharmaceuticals in Seattle. Unlike all of the currently approved anti-HIV drugs, which aim to reduce the amount of virus in the body by blocking viral replication, KP-1461 was designed not to inhibit replication, but rather to force newly created HIV to become less able to infect human cells.

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