关节假体钴中毒:危险患者的识别。

Alaska medicine Pub Date : 2010-09-01
Stephen Tower
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引用次数: 0

摘要

由于早期失败率高,并且担心翻修手术的结果会很差,MoM髋关节轴承正在接受仔细检查。然而,骨科医生和一般医学界都没有意识到,佩戴MoM轴承的患者也有患钴中毒的风险。医疗服务提供者需要知道,髋关节置换术植入者如果出现包括耳鸣、耳聋、眩晕、视觉改变、皮疹、甲状腺功能减退、震颤、用力时呼吸困难、情绪障碍、痴呆、心力衰竭和周围神经病变在内的综合症状,可能是关节假体钴中毒。这些病人需要询问他们是否做过髋关节置换术,如果做过,是什么类型的。对于那些植入了MoM轴承的患者或那些因陶瓷轴承失败而进行髋关节翻修的患者,建议获得[Co]。肾功能衰竭的MoM植入者患钴中毒的风险特别高。A [Co]可由许多参考实验室从静脉血的宝蓝顶微量元素管中测定。只要先抽出红色塞管,用标准针进行静脉穿刺就足够了。对骨科医生来说,MoM轴承的x线表现是很明显的。病人的手术报告通常会注明轴承类型。鉴于最近ASR轴承召回的宣传,担心髋关节植入物的患者将联系医疗提供者。大多数髋关节置换术患者不知道他们的轴承的品牌或材料。向患者提供髋关节植入物清单的副本可能会避免大多数髋关节置换术患者的担忧,因为他们没有风险。钴浓度大于7 mcg/l的患者需观察神经功能和心功能。那些钴含量大于20的患者应建议对其髋关节置换术进行翻修,以消除钴。大多数植入MoM轴承的患者体内的钴含量高于工业允许的水平,接触钴的工人可能会增加亚临床认知和心脏损伤的发生率。这种联系值得进一步研究。表1是本文先前引用数据的总结,可能有助于临床医生对a [Co]的解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Arthroprosthetic cobaltism: identification of the at-risk patient.

MoM hip bearings are being scrutinized due to high early failure rates and concerns that the results of the revision surgeries will be poor. However, orthopedic surgeons and the general medical community are unaware that patients with MoM bearings are also at risk for cobaltism. Medical providers need to know that hip arthroplasty implantees that present with symptom complexes that include tinnitus, deafness, vertigo, visual changes, rashes, hypothyroidism, tremor, dyspnea on exertion, mood disorders, dementia, heart failure, and peripheral neuropathy may be presenting arthroprosthetic cobaltism. These patients need to be asked if they have had a hip replacement and if so what type. For those patients implanted with a MoM bearing or those with a history of hip revision for a failed ceramic bearing obtaining a [Co] is indicated. MoM implantees with renal failure are a particularly high risk for cobaltism. A [Co] can be measured by many reference laboratories from royal blue top trace elements tube of venous blood. Venipuncture with a standard needle is adequate as long as a red stoppered tube is drawn first. The radiographic appearance of a MoM bearing is readily apparent to an orthopedic surgeon. The patient's operative report will usually specify the bearing type. Given that the publicity of the recent ASR bearing recall medical providers will be contacted by worried patients concerned about their hip implants. Most patients with hip replacements will not know the brand or material of their bearings. Providing patients with copies of their hip implant inventory might avoid worry by the majority of patients with hip arthroplasties that are not at risk. Patients with a cobalt levels of greater than 7 mcg/l bear observation of neurologic and cardiac function. Those patients with levels greater than 20 should be advised to have revision of their hip arthroplasty to a bearing that eliminates cobalt. Most patients implanted with MoM bearing have cobalt levels greater than those allowed in industry and cobalt exposed workers may have an increased incidence of subclinical cognitive and cardiac impairments. This association merits further study. Table 1 is a summation of the previously referenced data of this paper that might assist the clinician in interpreting a [Co].

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