{"title":"脑深部刺激是一种有望“治愈”成瘾的方法吗?","authors":"Wayne Hall, Adrian Carter","doi":"10.3410/M3-4","DOIUrl":null,"url":null,"abstract":"Deep brain stimulation has been put forward as a potential “cure” for intractable drug addiction. This is largely based on preclinical studies in animal models of addiction and small case series of positive, but short-term, effects on addictive behaviour in highly selected individuals. The history of neurosurgical treatment for psychiatric disorders suggests that we should be cautious in prematurely advocating invasive neurosurgical procedures on the basis of such limited evidence. Further research is required in animal models of addiction and in people treated for other neurological or psychiatric disorders before trials in addicted populations can be justified.","PeriodicalId":88480,"journal":{"name":"F1000 medicine reports","volume":"3 ","pages":"4"},"PeriodicalIF":0.0000,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/9e/medrep-03-04.PMC3042315.pdf","citationCount":"19","resultStr":"{\"title\":\"Is deep brain stimulation a prospective \\\"cure\\\" for addiction?\",\"authors\":\"Wayne Hall, Adrian Carter\",\"doi\":\"10.3410/M3-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Deep brain stimulation has been put forward as a potential “cure” for intractable drug addiction. This is largely based on preclinical studies in animal models of addiction and small case series of positive, but short-term, effects on addictive behaviour in highly selected individuals. The history of neurosurgical treatment for psychiatric disorders suggests that we should be cautious in prematurely advocating invasive neurosurgical procedures on the basis of such limited evidence. Further research is required in animal models of addiction and in people treated for other neurological or psychiatric disorders before trials in addicted populations can be justified.\",\"PeriodicalId\":88480,\"journal\":{\"name\":\"F1000 medicine reports\",\"volume\":\"3 \",\"pages\":\"4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/9e/medrep-03-04.PMC3042315.pdf\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"F1000 medicine reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3410/M3-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"F1000 medicine reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3410/M3-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is deep brain stimulation a prospective "cure" for addiction?
Deep brain stimulation has been put forward as a potential “cure” for intractable drug addiction. This is largely based on preclinical studies in animal models of addiction and small case series of positive, but short-term, effects on addictive behaviour in highly selected individuals. The history of neurosurgical treatment for psychiatric disorders suggests that we should be cautious in prematurely advocating invasive neurosurgical procedures on the basis of such limited evidence. Further research is required in animal models of addiction and in people treated for other neurological or psychiatric disorders before trials in addicted populations can be justified.