脂肪对数字x射线测量骨密度(DXR-BMD)的影响。

Edward Colt, Johan Kälvesten, Kenneth Cook, Nata Khramov, Fahad Javed
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摘要

目的:我们之前的研究表明,通过最新一代双能x射线吸收仪(DXA)扫描仪之一Lunar 'Intelligent DXA' (iDXA)测量,周围脂肪导致骨密度(BMD)增加高达21%[1]。我们研究的目的是看看在用数字x射线放射测量(DXR)测量II、III和IV掌骨骨密度时是否有可能避免这种伪影。方法:我们对一具尸体左手的骨头进行了x光检查,这些骨头被固定在一个木制的摇篮中,以保持近似的体内结构。将x射线数字化为医学数字成像和通信(DICOM)文件,使用dxr-online (dxr-online, Sectra,瑞典)进行分析,该文件使用与Pronosco X-posure v2和Sectra骨质疏松包相同的DXR-BMD算法。x光片重复了四次。然后我们用一层猪油把骨头包裹起来,再用x光拍了四次。重复这个过程,在骨头上涂上两层猪油,然后是三层猪油。结果:与未涂猪油组相比,涂2层或3层猪油组所测得的DXR-BMD最大增加0.44%。结论:DXR测量掌骨骨密度受周围猪油影响最小。用DXR测量掌骨骨密度似乎是一种避免由脂肪引起的骨密度人为变化的方法,当用DXA测量时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The effect of fat on the measurement of bone mineral density by digital X-ray radiogrammetry (DXR-BMD).

OBJECTIVE: We have previously shown that surrounding fat causes an increase of up to 21% in bone mineral density (BMD) measured by Lunar 'Intelligent DXA' (iDXA), one of the latest generation dual energy X-ray absorptiometry (DXA) scanners [1]. The purpose of our study was to see if it was possible to avoid this artifact when measuring the BMD of metacarpals II, III, and IV by digital X-ray radiogrammetry (DXR). METHODS: We took X-rays of the bones of a cadaveric left hand which were immobilized in a wooden cradle to preserve an approximate in vivo configuration. The X-rays were digitized into Digital Imaging and Communications in Medicine (DICOM) files which were analyzed using dxr-online (dxr-online, Sectra, Sweden) which uses the same DXR-BMD algorithm previously used by Pronosco X-posure v2 and Sectra Osteoporosis package. The X-rays were repeated four times. We then surrounded the bones with a layer of lard, and again X-rayed four times. This process was repeated with the bones were covered by two layers, and then three layers of lard. RESULTS: The measured DXR-BMD increased by a maximum of 0.44% when the metacarpals were covered by either two or three layers of lard compared with when the metacarpals were not covered by lard. CONCLUSION: The measurement of metacarpal BMD measured by DXR is minimally affected by surrounding lard. The measurement of metacarpal BMD by DXR seems to be a way of avoiding the artifactual change in BMD caused by fat, when it is measured by DXA.

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