Bjørn Mørkedal, Lars E Laugsand, Pål R Romundstad, Lars J Vatten
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引用次数: 21
摘要
背景:我们评估了铁状态与缺血性心脏病(IHD)死亡率的性别特异性关联,并探讨了这种关联的强度在随访期间是否发生了变化。设计:前瞻性队列研究。方法:在11.4年的随访期间,研究了28154名男性和32644名女性在基线时没有已知的心肌梗死或中风的IHD死亡率。结果:随访期间,1034名男性和女性死于IHD。与转铁蛋白饱和度最高的四分位数相比,与最低四分位数相关的多因素调整风险比在男性中为1.3 (95% CI 1.0-1.6),在女性中为1.4 (95% CI 1.0-1.9)。相应的血清铁风险比男性为1.5 (95% CI 1.1-1.9),女性为1.1 (95% CI 0.8-1.4),对于总铁结合能力(TIBC),男性最高与最低四分位数的风险比为0.9 (95% CI 0.8-1.2),女性为1.5 (95% CI 1.1-2.0)。与铁状态的关联在随访的早期比后期更强。结论:结果表明,低铁状态可能是IHD病理的晚期征兆,或者基线时未知的流行疾病可能影响这些关联。
Mortality from ischaemic heart disease: sex-specific effects of transferrin saturation, serum iron, and total iron binding capacity. The HUNT study.
Background: We assessed sex-specific associations of iron status with ischaemic heart disease (IHD) mortality and explored whether the strength of the associations changed during follow-up.
Design: Prospective cohort study.
Methods: During 11.4 years of follow-up, IHD mortality was studied in 28,154 men and 32,644 women without known myocardial infarction or stroke at baseline.
Results: During follow-up, 1,034 men and women died from IHD. Compared to being in the highest quartile of transferrin saturation, the multivariate adjusted hazard ratio associated with being in the lowest quartile was 1.3 (95% CI 1.0-1.6) in men and 1.4 (95% CI 1.0-1.9) in women. The corresponding hazard ratios for serum iron were 1.5 (95% CI 1.1-1.9) in men and 1.1 (95% CI 0.8-1.4) in women, and for total iron binding capacity (TIBC), the hazard ratio of being in the highest compared to the lowest quartile was 0.9 (95% CI 0.8-1.2) in men and 1.5 (95% CI 1.1-2.0) in women. Associations with iron status were stronger in the early than in later stages of follow-up.
Conclusions: The results suggest that low iron status may be a late sign of IHD pathology or that unknown prevalent disease at baseline could influence the associations.