全血细胞减少症发生后再次成功引入丙戊酸

American Journal Geriatric Pharmacotherapy Pub Date : 2011-10-01 DOI:10.1016/j.amjopharm.2011.09.003

Jonathan T. Stewart MD

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引用次数: 4

摘要

背景丙戊酸与多种血液学异常有关，最常见的是血小板减少症。全血细胞减少症不太常见，而且可能更严重。对于丙戊酸钠引起的全血细胞减少症的自然过程知之甚少。病例总结:我们报告了一位在服用丙戊酸治疗双相情感障碍时出现全血细胞减少症的患者。在对其他几种情绪稳定剂无效后，在密切血液学监测的情况下谨慎地重新引入丙戊酸。全血细胞减少症在过去6个月内未复发。结论:尽管需要谨慎，但血小板减少可能不是继续丙戊酸治疗的绝对禁忌症。

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Successful Reintroduction of Valproic Acid After the Occurrence of Pancytopenia

Background

Valproic acid is associated with a variety of hematologic abnormalities, most commonly thrombocytopenia. Pancytopenia is much less common and potentially much more serious. Little is known about the natural course of valproate-induced pancytopenia.

Case summary

We present a patient who developed pancytopenia while taking valproic acid for bipolar illness. After failing to respond to several other mood stabilizers, valproic acid was cautiously reintroduced with close hematologic monitoring. The pancytopenia has not recurred in the past 6 months.