在疼痛抑制模式下的尾状核和岛岛的激活比较热刺激和电刺激。

Q4 Medicine Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-01-18 DOI:10.2174/1874440001105010001
Arthur P Wunderlich, Roland Klug, Gregor Stuber, Bernhard Landwehrmeyer, Frank Weber, Wolfgang Freund
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引用次数: 40

摘要

疼痛调节是神经系统不可或缺的功能。它需要适应慢性刺激。为了深入了解疼痛抑制机制,我们比较了两项使用相同刺激范式的不同刺激方式(热刺激和电刺激)抑制疼痛感觉的研究:15名受试者在抑制疼痛感觉的指导下,分别对双手进行刺激。在两项单模态研究中都发现了前脑岛和DLPFC的激活,这似乎是疼痛抑制的共同特征,因为在本文的相互作用分析中没有发现。在抑制疼痛感的任务中,在热刺激下没有一致的更强的激活。但在电刺激时,双侧尾状核和对侧后岛的激活明显强于热刺激。这可能是由于与热刺激相比,痛觉电刺激具有更高的感觉鉴别内容,更需要主观评价和抑制。尾状核似乎不仅在运动系统中起重要作用,而且在疼痛体验的调节中也起重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.

Pain modulation is an integral function of the nervous system. It is needed to adapt to chronic stimuli. To gain insights into pain suppression mechanisms, two studies concerning the suppression of the feeling of pain with different stimulation modalities (heat vs. electrical stimuli) but using the same stimulation paradigms were compared: 15 subjects each had been stimulated on both hands under the instruction to suppress the feeling of pain. Anterior insula and DLPFC activation was seen in both single modality studies and seems to be a common feature of pain suppression, as it is absent in the interaction analyses presented here. During the task to suppress the feeling of pain, there were no consistent activations stronger under thermostimulation. But during electrostimulation, there was significantly stronger activation than during thermal stimulation in the caudate nucleus bilaterally and in the contralateral posterior insula. This may be attributed to the higher sensory-discriminative content and more demand on subjective rating and suppression of the painful electrical stimulus, compared to thermostimulation. The caudate nucleus seems to play an important role not only in the motor system but also in the modulation of the pain experience.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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