G1和G2对渗透冲击的反应是出芽酵母细胞周期的强大特性。

Christian Waltermann, Max Floettmann, Edda Klipp
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引用次数: 0

摘要

布尔模型成功地应用于出芽酵母细胞周期,证明了其结构和时间都是稳健设计的。然而,从这些研究中,很少有结论可以得出细胞周期阻滞在渗透应激和信息素暴露可能是多么强大。因此,我们实现了酿酒酵母细胞周期的紧凑布尔模型,包括其与高渗透压甘油(HOG)和信息素途径的界面。我们表明,在没有应力输入的情况下,我们模型的所有初始状态都稳健地收敛到循环吸引子,而信息素暴露和渗透应力导致收敛到单态状态,对应于硅中的G1和G2捕获。与随机布尔网络的比较表明,渗透胁迫下的细胞周期阻滞是酵母细胞周期的一个高度稳健的特性。我们使用新颖的前端布尔netgui在python软件布尔netb上实现了我们的模型。
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G1 and G2 arrests in response to osmotic shock are robust properties of the budding yeast cell cycle.

Boolean modeling has been successfully applied to the budding yeast cell cycle to demonstrate that both its structure and its timing are robustly designed. However, from these studies few conclusions can be drawn how robust the cell cycle arrest upon osmotic stress and pheromone exposure might be. We therefore implement a compact Boolean model of the S. cerevisiae cell cycle including its interfaces with the High Osmolarity Glycerol (HOG) and the pheromone pathways. We show that all initial states of our model robustly converge to a cyclic attractor in the absence of stress inputs whereas pheromone exposure and osmotic stress lead to convergence to singleton states which correspond to G1 and G2 arrest in silico. A comparison with random Boolean networks reveals, that cell cycle arrest under osmotic stress is a highly robust property of the yeast cell cycle. We implemented our model using the novel frontend booleannetGUI to the python software booleannet.

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