hepascore作为慢性丙型肝炎感染患者肝纤维化预测因子的验证

Hepatitis research and treatment Pub Date : 2011-01-01 Epub Date: 2011-12-28 DOI:10.1155/2011/972759
Hamid Kalantari, Hannan Hoseini, Anahita Babak, Majid Yaran
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引用次数: 21

摘要

介绍。肝活检是一种有创性的肝纤维化诊断方法。血清生物标志物可能作为肝活检的替代方法,用于评估慢性丙型肝炎患者的纤维化程度。采用简单非随机抽样方法,将80例慢性丙型肝炎患者纳入研究。完成肝活检后,根据METAVIR评分系统对患者进行分类。Hepascore算法是基于年龄、性别和血清总胆红素、δ-谷氨酰转移酶、α2-巨球蛋白和透明质酸水平计算的。采用spearman检验和ROC检验。结果。肝活检结果显示,F0、F1、F2、F3、F4分别为12例、25例、20例、7例、16例。对于0.34的临界值,Hepascore诊断显著纤维化的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)分别为67%、56%、64%和56%。对于Hepascore临界值0.61,PPV和NPB诊断严重纤维化的敏感性、特异性分别为82%、86%、70%和92%。对于Hepascore分界点0.84,诊断肝硬化的敏感性、特异性、PPV和NPB分别为100%、97%、89%和100%。结论。Hepascore在诊断纤维化水平,特别是肝硬化方面有很高的价值。因此,可用于患者的初步筛查,以确定是否需要肝活检。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Validation of hepascore as a predictor of liver fibrosis in patients with chronic hepatitis C infection.

Introduction. Liver biopsy is an invasive determinator for hepatic fibrosis. Serum biomarkers can probably be used as an alternative to liver biopsy in assessment of the degree of fibrosis in patients with chronic Hepatitis C. Method. Eighty patients with chronic Hepatitis C were included in the study using simple nonrandom sampeling metod. After fulfillment of liver biopsy, the patients were categorized according to the METAVIR Scoring system. The Hepascore algorithm is computed based on age, sex, and the serum levels of total bilirubin, δ-glutamyl transferase, α2-Macroglobulin, and hyaluronic acid. The spearman and ROC tests were used. Results. According to the liver biopsy results, 12, 25, 20, 7 and 16 patients had F0, F1, F2, F3, and F4, respectively. With regard to the 0.34 cut-off point Hepascore had 67%, 56%, 64%, and 56% sensitivity, specificity, respectively, positive prediction value (PPV), and negative prediction value (NPV), respectively, for diagnosis of significant fibrosis. For a Hepascore cut-off point 0.61, sensitivity, specificity, respectively, PPV and NPB 82%, 86%, 70%, and 92% in diagnosis of severe fibrosis. For a Hepascore cut-off point 0.84, sensitivity, specificity, PPV and NPB were respectively 100%, 97%, 89%, and 100% for diagnosis of cirrhosis. Conclusion. Hepascore has a high value in diagnosis of the level of fibrosis, particularly cirrhosis. Therefore, it can be used for primary screening of patients to determine the need for liver biopsy.

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