生物分子自卫和高特异性靶向治疗的无效性。

Gene regulation and systems biology Pub Date : 2011-01-01 Epub Date: 2011-11-21 DOI:10.4137/GRSB.S8542
Simon Rosenfeld
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引用次数: 10

摘要

长期以来,稳健性一直被认为是生物实体的独特属性。虽然关于稳健性的概念意义已经达成了相当广泛的共识,但这种系统特性背后的生物分子机制仍有许多未解决的问题。本文的目的是提供一个概述现有的方法来表征稳健性在数学上合理的条款。鲁棒性的概念在网络脆弱性、非线性动态稳定性和自组织等不同的背景下被讨论。第二个目标是讨论生物稳健性对个体靶点治疗的影响,以及战胜由此产生的耐药性的可能策略。特别关注群体智能的概念,这是一种在自然、社会和人工系统中得到充分研究的自组织机制。假设群体智能是理解化学耐药性涌现特性的关键。
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Biomolecular self-defense and futility of high-specificity therapeutic targeting.

Robustness has been long recognized to be a distinctive property of living entities. While a reasonably wide consensus has been achieved regarding the conceptual meaning of robustness, the biomolecular mechanisms underlying this systemic property are still open to many unresolved questions. The goal of this paper is to provide an overview of existing approaches to characterization of robustness in mathematically sound terms. The concept of robustness is discussed in various contexts including network vulnerability, nonlinear dynamic stability, and self-organization. The second goal is to discuss the implications of biological robustness for individual-target therapeutics and possible strategies for outsmarting drug resistance arising from it. Special attention is paid to the concept of swarm intelligence, a well studied mechanism of self-organization in natural, societal and artificial systems. It is hypothesized that swarm intelligence is the key to understanding the emergent property of chemoresistance.

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