M Goergen, D Manzoni, V De Blasi, P Fabiano, V Poulain, L De Magistris, V Simonelli, K Dahan, J-S Azagra
{"title":"肥胖易感基因座(MC4R和INSIG2)对胃旁路治疗肥胖患者体重减轻和合并症改善的影响","authors":"M Goergen, D Manzoni, V De Blasi, P Fabiano, V Poulain, L De Magistris, V Simonelli, K Dahan, J-S Azagra","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.</p><p><strong>Objective: </strong>We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.</p><p><strong>Design: </strong>A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.</p><p><strong>Results: </strong>After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.</p><p><strong>Conclusions: </strong>The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.</p>","PeriodicalId":72476,"journal":{"name":"Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.\",\"authors\":\"M Goergen, D Manzoni, V De Blasi, P Fabiano, V Poulain, L De Magistris, V Simonelli, K Dahan, J-S Azagra\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.</p><p><strong>Objective: </strong>We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.</p><p><strong>Design: </strong>A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.</p><p><strong>Results: </strong>After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.</p><p><strong>Conclusions: </strong>The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.</p>\",\"PeriodicalId\":72476,\"journal\":{\"name\":\"Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.
Background: Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.
Objective: We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.
Design: A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.
Results: After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.
Conclusions: The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.
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