类固醇致乙状结肠憩室穿孔1例颞动脉炎:罕见的临床病理。

Q3 Medicine Clinical Medicine Insights- Pathology Pub Date : 2012-01-01 Epub Date: 2012-03-29 DOI:10.4137/CPath.S7924
Bulent Kaya, Orhan Aras, Orhan Bat, Nuriye Esen Bulut, Kemal Memisoglu
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引用次数: 7

摘要

皮质类固醇用于治疗包括颞动脉炎在内的许多风湿病。皮质类固醇治疗过程中出现胃肠道穿孔是一种严重的并发症。Beck等在1950年首次报道了类固醇使用后的结肠穿孔。虽然其病理生理机制尚不清楚,但有人认为类固醇可能是通过扰乱肠黏膜屏障,促进肠道穿孔。长期使用皮质类固醇治疗会增加结肠穿孔的风险。我们报告一位因颞动脉炎而服用皮质类固醇两年并因乙状结肠憩室穿孔而手术的患者。
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Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology.

Corticosteroids are used in the treatment of many rheumatological diseases including temporal arteritis. The gastrointestinal perforation during corticosteroid treatment is a serious complication. Colon perforation after steroid use was first reported by Beck et al in 1950.1 Although the pathophysiological mechanism is not understood clearly, it is claimed that steroids probably by disturbing the intestinal mucosal barrier, facilitate the intestinal perforation. The long term treatment with corticosteroids increases the risk of colon perforation. We are presenting a patient who was taking corticosteroid due to temporal arteritis for two years and operated with sigmoid diverticular perforation.

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