他汀类药物对参与逆向胆固醇转运的基因影响的分子机制。

Alvaro Cerda, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
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引用次数: 15

摘要

许多临床试验和科学研究数据表明,他汀类药物除了具有降低低密度脂蛋白(LDL)胆固醇的作用外,还对高密度脂蛋白(HDL)代谢有影响。这些作用被认为是重要的抗动脉粥样硬化特性,有助于进一步降低心血管疾病的风险。参与逆向胆固醇转运(RCT)的基因调控是非常复杂的,他汀类药物治疗所发挥的调节作用尚不清楚。在这篇综述中,我们讨论了控制RCT的基因调控的分子机制,特别强调了他汀类药物的组织特异性作用。他汀类药物对参与RCT不同阶段(外周组织胆固醇外排,血浆中HDL代谢和肝脏内化)的基因的调节进行了总结。本文还讨论了最近关于microrna调控的新机制的报道。
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Molecular mechanisms underlying statin effects on genes involved in the reverse cholesterol transport.

Many clinical trials and data from scientific investigations have suggested the effects of statins on high-density lipoprotein (HDL) metabolism, besides their actions in reducing low-density lipoprotein (LDL) cholesterol. These actions have been proposed as important anti-atherogenic properties that contribute to the additional reduction of risk for cardiovascular diseases. The regulation of genes involved in the reverse cholesterol transport (RCT) is very complex and the modulation exerted by statin treatment is poorly understood. In this review, we discuss the molecular mechanisms underlying the modulation of genes controlling the RCT with special emphasis on the reported tissue-specific effects of statins. The statin modulation of genes participating in the different stages of RCT (cholesterol efflux from peripheral tissues, HDL metabolism in the plasma and internalization by the liver) has been summarized. Recent reports on novel mechanisms of regulation by microRNAs are also discussed.

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