{"title":"1-(2-萘基)-2-(咪唑-1-基)乙酮肟o -烷基化衍生物的合成及抗惊厥活性。","authors":"R Bansal, P Chauhan, R Sharma","doi":"10.1055/s-0032-1316377","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, O-alkylated derivatives of nafimidone oxime chemically, 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime have been synthesized as potential anticonvulsant compounds. O-alkylation of the oxime using hydrochlorides of various dialkylaminoethyl chlorides, methyl chloroacetate and alkyl dihalides gave the O-alkylated derivatives. Anticonvulsant activity of the compounds was determined against pentylenetetrazole induced convulsions in mice. The newly synthesized compounds exhibited moderate to significant activity compared to diazepam.</p>","PeriodicalId":56084,"journal":{"name":"Arzneimittel-Forschung-Drug Research","volume":"62 9","pages":"420-4"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0032-1316377","citationCount":"2","resultStr":"{\"title\":\"Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime.\",\"authors\":\"R Bansal, P Chauhan, R Sharma\",\"doi\":\"10.1055/s-0032-1316377\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, O-alkylated derivatives of nafimidone oxime chemically, 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime have been synthesized as potential anticonvulsant compounds. O-alkylation of the oxime using hydrochlorides of various dialkylaminoethyl chlorides, methyl chloroacetate and alkyl dihalides gave the O-alkylated derivatives. Anticonvulsant activity of the compounds was determined against pentylenetetrazole induced convulsions in mice. The newly synthesized compounds exhibited moderate to significant activity compared to diazepam.</p>\",\"PeriodicalId\":56084,\"journal\":{\"name\":\"Arzneimittel-Forschung-Drug Research\",\"volume\":\"62 9\",\"pages\":\"420-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1055/s-0032-1316377\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arzneimittel-Forschung-Drug Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0032-1316377\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/7/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arzneimittel-Forschung-Drug Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0032-1316377","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/7/12 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime.
In this study, O-alkylated derivatives of nafimidone oxime chemically, 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime have been synthesized as potential anticonvulsant compounds. O-alkylation of the oxime using hydrochlorides of various dialkylaminoethyl chlorides, methyl chloroacetate and alkyl dihalides gave the O-alkylated derivatives. Anticonvulsant activity of the compounds was determined against pentylenetetrazole induced convulsions in mice. The newly synthesized compounds exhibited moderate to significant activity compared to diazepam.
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