罗格列酮与胰岛素联合治疗对糖尿病大鼠左心室肌氧化应激及血脂的影响。

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-07-05 DOI:10.1155/2012/905683
Servet Kavak, Lokman Ayaz, Mustafa Emre
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引用次数: 7

摘要

目的:在本研究中,我们验证了罗格列酮(RSG)和胰岛素能够通过预防NAD(P)H氧化酶激活来抑制高糖引起的氧化应激的假设。方法和材料:雄性白化Wistar大鼠随机分为未经治疗的对照组(C)、单次腹腔注射链脲佐菌素(45mg kg(-1))的糖尿病组(D)和每天两次灌胃RSG和每天一次皮下注射胰岛素的罗格列酮组(B组)。测定循环中HbA1c和血糖水平以及左心室肌中丙二醛和3-硝基酪氨酸水平。结果:用B组治疗D大鼠可使血糖呈时间依赖性下降。我们发现,B组大鼠的脂质状况和HbA1c水平在治疗期结束时达到了对照组D大鼠的值。与C组相比,D组的3-硝基酪氨酸水平升高。与D组相比,B组的丙二醛和3-硝基酪氨酸含量降低(P<0.05)。因此,在糖尿病相关的血管疾病中,B组治疗可能具有心脏保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effects of rosiglitazone with insulin combination therapy on oxidative stress and lipid profile in left ventricular muscles of diabetic rats.

Purpose: In this study, we tested the hypothesis that rosiglitazone (RSG) with insulin is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation.

Methods and materials: Male albino Wistar rats were randomly divided into an untreated control group (C), a diabetic group (D) that was treated with a single intraperitoneal injection of streptozotocin (45 mg kg(-1)), and rosiglitazone group that was treated with RSG twice daily by gavage and insulin once daily by subcutaneous injection (group B). HbA1c and blood glucose levels in the circulation and malondialdehyde and 3-nitrotyrosine levels in left ventricular muscle were measured.

Result: Treatment of D rats with group B resulted in a time-dependent decrease in blood glucose. We found that the lipid profile and HbA1c levels in group B reached the control group D rat values at the end of the treatment period. There was an increase in 3-nitrotyrosine levels in group D compared to group C. Malondialdehyde and 3-nitrotyrosine levels were found to be decreased in group B compared to group D (P < 0.05).

Conclusion: Our data suggests that the treatment of diabetic rats with group B for 8 weeks may decrease the oxidative/nitrosative stress in left ventricular tissue of rats. Thus, in diabetes-related vascular diseases, group B treatment may be cardioprotective.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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