Understanding how the brain ensures its energy supply.

The theme of this research topic emerged in the hope of elucidating the mechanisms of energy supply dictated by costly neuronal activity. The versatility of the papers accepted to the topic is surprisingly broad. Three trends became evident, presumably reflecting the most vivid interests in the field: (1) the “in vivo versus in vitro” problem; (2) the role of particular energy substrates; and (3) the macro-level of energy homeostasis and how it applies to the dietary manipulations aimed at treatment of neurodegenerative disorders.