家族式的设计。

IARC scientific publications Pub Date : 2011-01-01

Christopher I Amos, Christoph Lange

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引用次数: 0

摘要

基于家庭的设计在遗传流行病学中用于各种原因，包括对疾病的遗传影响强度的初步估计，遗传联系分析，遗传原因可以亚定位到染色体区域，以及进行不受种族背景影响的关联研究。本章描述了在疾病遗传成分的初始特征和基于家族的关联分析和与遗传标记的联系设计中所遵循的一些方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Family-based designs.

Family-based designs are used for a variety of reasons in genetic epidemiology, including the initial estimation of the strength of genetic effects for a disease, genetic linkage analysis by which genetic causes can be sublocalized to chromosomal regions, as well as to perform association studies that are not confounded by ethnic background. This chapter describes some of the approaches that are followed in the initial characterizing of genetic components of disease and family-based designs for association analysis and linkage with genetic markers.

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